The index closed 15.2 points lower after losing nearly 40 points on September 25. It is now at the lowest in 11 weeks.
Trading on the Ho Chi Minh Stock Exchange (HoSE), on which the index is based, fell 8% to VND21.62 trillion ($885 million).
Foreign investors were net buyers to the tune of VND651 billion, mainly buying HPG of steelmaker Hoa Phat Group and SSI of leading brokerage SSI Securities Corporation.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.76% while the UPCoM-Index for the Unlisted Public Companies Market dropped 0.30%.