Brazil ran out with a new-look side, with coach Tite giving debuts to goalkeeper Neto and full-back Eder Militao as well as first starts to Richarlison at centre forward and Arthur in midfield.
The new boys looked completely at home against a team ranked 72nd in the world and Brazil took just three minutes to open the scoring when Neymar slotted home a penalty after Richarlison had been brought down in the box.
Richarlison got his name on the scoresheet 13 minutes later when he curled a spectacular shot into the top corner from 15 meters out and on the half hour mark Brazil made it 3-0, Phillipe Coutinho firing home from the edge of the box after Neymar laid the ball into his path.
Both sides made changes at halftime but the five-times world champions took just five more minutes to get a fourth goal, with Richarlison scoring his second when he pounced onto a loose ball to rifle home a low shot from inside the box.
Marquinhos got Brazil a fifth in the final minute when he headed home a corner from Neymar.
Brazil’s next games will be friendlies in Saudi Arabia against the host nation on Oct. 12 and then Argentina four days later.
Argentina and Colombia drew 0-0 in a friendly in New Jersey on Tuesday in a game that did little to cheer fans of either side hoping for a boost after disappointing World Cup showings.
Colombian goalkeeper David Ospina made a fine diving save to tip an Exequiel Palacios shot over the bar after six minutes while his Argentine counterpart Franco Armani was the busier of the two in the second half but neither side looked like breaking the deadlock.
Both sides used stand-in coaches for the game, with Jose Pekerman resigning as Colombia boss last week and Argentina still to replace Jorge Sampaoli, who left his post after the World Cup.
Argentina, who were without Lionel Messi, fielded a young side and they were unable to make much headway against the more experienced Colombians.
Argentina's next match is scheduled for Oct. 16 against Brazil in Saudi Arabia, while Colombia will take on the United States in Tampa, also in October.