The event is expected to draw more than 500 foreign and domestic competing in the 10km, 21km and 42km categories.
Runners will start from Dong Van town, home of Dong Van Karst Plateau Geopark, through Ma Pi Leng Pass and Meo Vac town and finish in Dong Van district.
The event is organised by the Ha Giang Department of Culture, Sports, Tourism and Vietnam Athletics Federation.
The Ma Pi Leng pass is known as the king of all mountain passes in Vietnam.